The good news on bladder pain especially Painful Bladder Syndrome, is that in more than. When symptoms disappear because of a change in diet or other treatments are employed, they may return after a few days, weeks, months, or even years. Unfortunately, scientists have no idea why. The severity of your bladder pain may mean trying a combination of different treatment options to see what works best for you. It also makes sense to discuss your options with your doctor. Treatment options might include a combination of both lifestyle changes and medical treatments.